Reactivation of adult-onset Still's disease after use of the COVID-19 ChAdOx1-S vaccine.

A woman in her 60s with a history of adult-onset Still's disease (AOSD) in remission for 14 years received the ChAdOx1-S vaccine as a booster to her initial vaccination schedule (two doses of CoronaVac vaccine 6 months apart). Two weeks later, she consulted for symptoms suggestive of AOSD reactivation. This was confirmed during hospitalisation, where renal and cardiac involvement were also observed. Despite using high-dose corticosteroids, troponin T and N-terminal pro hormone B-type natriuretic peptide (NT-proBNP) were persistently elevated. Tocilizumab was used, with which the patient achieved complete remission of her symptoms and normalised her laboratory tests.

MUCORMICOSE EM PACIENTES PÓS COVID-19: RELATO DE TRÊS CASOS

Introdução A mucormicose é uma infecção angioinvasiva causada por fungos filamentosos ubíquos que acomete especialmente pacientes imunocomprometidos. Diabetes mellitus, neoplasias hematológicas, uso prolongado de glicocorticoides, imunossupressão por transplante de órgãos e síndrome da imunodeficiência adquirida são fatores de risco. Tal entidade ganhou especial atenção nos últimos dois anos devido ao aumento de casos em pacientes com COVID-19 tratados com corticoterapia. Objetivo Relatar três casos de mucormicose em pacientes internados em hospital terciário com histórico de COVID-19 que receberam corticoterapia endovenosa em altas doses. Método Caso 1: homem, 69 anos, diabético. Quatorze dias após alta hospitalar apresentou dor e mobilidade dentária. Imagem radiológica evidenciou abscessos em seio maxilar direito e erosões ósseas. Submetido a maxilectomia e remoção de arco zigomático e de partes moles acometidas. Biópsia com hifas compatíveis com Mucor spp. Feito dose acumulada de 8350 mg de anfotericina B lipossomal com boa evolução clínica. Caso 2: homem, 70 anos, apresentou múltiplos abscessos em calota craniana e órbita à esquerda após 20 dias do início de corticoterapia. Realizada a exenteração orbitária, ressecção de parede lateral de órbita e de múltiplos ossos da face, crânio e partes moles adjacentes. Além da biópsia compatível, houve crescimento de Mucor spp em cultura. Feito dose acumulada de anfotericina complexo lipídico de 14900 mg, com boa evolução clínica. Caso 3: homem, 44 anos, diabético, apresentou quadro de sinusite 11 dias após início da corticoterapia. Imagem radiológica mostrou extenso acometimento de ossos frontais e zigomáticos e abscessos em seios frontais e etmoidais. Submetido a maxilectomia esquerda ampliada para parede lateral de órbita e osso zigomático, palatectomia esquerda e drenagem de abscessos. Biópsia foi compatível e houve crescimento de Rhizopus spp em cultura. Feito dose acumulada de anfotericina complexo lipídico de 11600 mg, também com boa evolução. Resultados A mucormicose é uma doença rara, porém emergente e com altas taxas de mortalidade. Os casos descritos evoluíram bem clinicamente apesar da extrema gravidade e seguem com quadro estável. Pode-se atribuir como fatores determinantes a associação da abordagem cirúrgica extensa e precoce aliada ao início de terapia antifúngica. Conclusão Assim, é necessário a suspeição diagnóstica precoce, devido ao grande benefício da terapia medicamentosa e desbridamento cirúrgico em fases iniciais da doença.

A Rarity Among the Rare: Psychiatric Manifestations in a Young Woman With Stiff-Person Syndrome.

Stiff-person syndrome (SPS) is a rare progressive neurologic disease associated with autoantibodies against glutamic acid decarboxylase, an intracellular enzyme involved in the production of gamma-aminobutyric acid.  We present a case involving a 35-year-old Haitian female who was placed under the Baker Act in the emergency department for suicidal behavior and acute psychosis. She has a history of SPS with a positive glutamic acid decarboxylase (GAD) antibody, a condition most commonly found in females between 20 and 50 years of age. The condition was managed by an outpatient neurologist using diazepam, baclofen, and monthly intravenous immunoglobulin treatments. She also has an extensive history of organic neurological conditions, including traumatic brain injury at 18 years old and COVID-19-related anoxic encephalitis that occurred in December 2020. Both psychiatric and neurological physical exams were completed. They revealed a cerebellar tremor, bilateral ptosis, poor eye contact, decreased concentration, poor insight, depressed mood, flat affect, poor judgement, delusional thoughts and a disorganized thought process with tangential speech. CT and MRI imaging of the brain showed no acute intracranial abnormalities. A quantitative titer of the GAD antibody was completed and shown to be elevated >250IU/mL. Depakote 500mg twice daily and risperidone 3mg twice daily were prescribed. The patient had progressive improvement of psychosis including delusional thoughts over the following five days and was able to be discharged with instructions to follow-up with outpatient neurology.

Ruxolitinib as a treatment strategy for SARS-CoV-2 pneumonia: clinical experience in a real-world setting.

INTRODUCTION: Severe acute respiratory syndrome-related coronavirus (SARS-CoV-2) infection is characterised by a viral phase and a severe pro-inflammatory phase. The inhibition of the JAK/STAT pathway limits the pro-inflammatory state in moderate to severe COVID-19. METHODOLOGY: We analysed the data obtained by an observational cohort of patients with SARS-CoV-2 pneumonia treated with ruxolitinib in 22 hospitals of Mexico. The applied dose was determined based on physician's criteria. The benefit of ruxolitinib was evaluated using the 8-points ordinal scale developed by the NIH in the ACTT1 trial. Duration of hospital stay, changes in pro-inflammatory laboratory values, mortality, and toxicity were also measured. RESULTS: A total of 287 patients were reported at 22 sites in Mexico from March to June 2020; 80.8% received ruxolitinib 5 mg BID and 19.16% received ruxolitinib 10 mg BID plus standard of care. At beginning of treatment, 223 patients were on oxygen support and 59 on invasive ventilation. The percentage of patients on invasive ventilation was 53% in the 10 mg and 13% in the 5 mg cohort. A statistically significant improvement measured as a reduction by 2 points on the 8-point ordinal scale was described (baseline 5.39 ± 0.93, final 3.67± 2.98, p = 0.0001). There were 74 deaths. Serious adverse events were presented in 6.9% of the patients. CONCLUSIONS: Ruxolitinib appears to be safe in COVID-19 patients, with clinical benefits observed in terms of decrease in the 8-point ordinal scale and pro-inflammatory state. Further studies must be done to ensure efficacy against mortality.

Health outcomes in redlined versus non-redlined neighborhoods: A systematic review and meta-analysis.

BACKGROUND: Redlining was a racialized zoning practice in the U.S. that blocked fair access to home loans during the 1930s, and recent research is illuminating health problems in the current residents of these historically redlined areas. However, this work has not yet been holistically summarized. Here, we present the first systematic review and meta-analysis comparing health outcomes in redlined versus non-redlined neighborhoods in U.S. cities. METHODS: We extracted relevant articles in PubMed, Web of Science, Cochrane and Science Direct databases published from January 2010 to September 2021. RESULTS: The search revealed 12 studies on preterm births (n = 3), gunshot-related injuries (n = 2), cancer (n = 1), asthma (n = 1), self-rated health (n = 1), multiple health outcomes (n = 2), heat-related outcomes (n = 1) and COVID-19 incidence and mortality (n = 1). A meta-analysis of three studies found the odds of having preterm birth was significantly higher (OR = 1.41, 95% CI: 1.05, 1.88; p = 0.02) among women living in redlined areas compared to those in non-redlined areas. Review of other outcomes revealed that gunshot-related injuries, asthma, heat-related outcomes, and multiple chronic conditions were worse in redlined areas, while associations with cancer varied by cancer type. In terms of cause-specific mortality, one study revealed no link between residential redlining and infant mortality rate, while one study on COVID-19 outcomes was inconclusive. CONCLUSIONS: Overall, this review presents evidence that living in historically redlined areas is associated with increased risk of multiple serious adverse health outcomes. Further research on mechanisms, remediation, and neighborhood-level interventions is needed to strengthen the understanding of the impacts of redlining on health.

Management of Persistent SARS-CoV-2 Infection in Patients with Follicular Lymphoma.

INTRODUCTION: There is no consensus on the management of the coronavirus disease (COVID-19) in patients with secondary immunosuppression due to either an underlying hematological disease or to the effects of immunochemotherapy (ICT). Some of them may present persistent infection with multiple relapses of COVID-19, requiring several admissions. This study evaluated the clinical characteristics and outcomes after treatment of 5 patients with follicular lymphoma (FL), previously treated with ICT, who developed several episodes of COVID-19. METHODS: We analyzed the clinical evolution and response to treatment with antiviral agent, steroids, and convalescent plasma in 5 patients with FL and severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) persistent infection. Reverse transcriptase polymerase chain reaction tests and peripheral blood immunophenotype were performed for all patients. RESULTS: All patients required hospitalization due to pneumonia with severity criteria and were re-admitted after a median of 22 days (13-42) from the previous discharge. They all showed B-cell depletion by immunophenotyping, and no traces of immunoglobulin antibodies against SARS-CoV-2 were detected in any of the cases. The survival rate was 80%. CONCLUSION: The combination therapy evidenced clinical benefits, demonstrating its capacity to control infection in immunosuppressed FL patients treated with ICT.

Daño colateral de la pandemia por COVID-19 en centros privados de salud de Argentina

To contain the coronavirus pandemic (COVID-19), a strict nationwide lockdown has been enforced and the health systems have been reorganized to deal with this entity. During this period, changes in the care of non-infectious diseases have been observed. Our aim was to describe the impact of the COVID-19 pandemic in the care of non-communicable diseases. A structured retrospective survey was carried out in 31 healthcare centers affiliated with the Asociación de Clínicas, Sanatorios y Hospitales Privados de la República Argentina y Cámara de Entidades de Diagnóstico y Tratamiento. We compared data for April 2019 versus April 2020 regarding emergency room consultations, hospital admissions, invasive procedures and treatments, and bed occupancy. In April 2020, we observed a decrease in emergency room visits (75%) and hospitalizations (48%). A 62% decrease in admissions was noted for angina pectoris and acute coronary syndromes and a 46% decrease in admissions for stroke and transient ischemic attack. A meaningful decrease was found in coronary angioplasties (59%) and total percutaneous interventions (65%), and also a decrease in general surgeries (73%), and cardiac surgeries (58%). Although social distancing measures are a key public health strategy to flatten the infection curve, the observed decrease in medical visits and interventions may impact negatively on cardiovascular, cerebrovascular and cancer related morbidity and mortality. A collective effort is required to avoid the unintended consequences and collateral damage of the COVID-19 pandemic.

Impact of COVID-19 Pandemic on Patients with Immune Thrombocytopaenia.

Background and Objectives: The aim of this study was to determine the impact of the COVID-19 pandemic on the lives of patients with immune thrombocytopaenia (ITP) treated at our hospital. Materials and Methods: The study was conducted in the Community of Madrid, which has the highest number of COVID-19 cases in Spain. We included 143 adult patients with ITP (130 with chronic ITP, 8 with persistent ITP, and 5 with newly diagnosed ITP). We conducted a telephone survey to collect the data and created a registry. Materials and Methods: Overall, 24 patients presented symptoms suggestive of COVID-19, which was confirmed by RT-PCR in 8 cases. The cumulative incidence of confirmed SARS-CoV-2 infection was higher in the patients with ITP than in the Madrid population. There were no differences in the disease incidence or clinical course of infection in the patients treated with immunosuppressants. Almost all of the patients reported adherence to the prescribed treatment, although 49.2% of the hospital visits were either cancelled or postponed, 17.2% because of the patients' fear of coming to the centre. Nearly half of the cohort was considered vulnerable, and 17% had been granted a dependency or disability benefit. Conclusions: COVID-19 had a major impact on the psychosocial, occupational, and quality of care of patients with ITP.

Daño colateral de la pandemia por COVID-19 en centros privados de salud de Argentina

Para contener la pandemia de COVID-19 se han adoptado medidas nacionales estrictas de aislamiento social y se han reorganizado los sistemas de salud. En este período, se observaron cambios en la atención de enfermedades no infecciosas. El objetivo de este trabajo fue describir las consecuencias de la pandemia de COVID-19 sobre la atención de enfermedades no transmisibles. Se realizó una encuesta estructurada retrospectiva a 31 centros asistenciales de la Asociación de Clínicas, Sanatorios y Hospitales Privados de la República Argentina y Cámara de Entidades de Diagnóstico y Tratamiento. Se compararon indicadores de abril de 2019 versus abril 2020. Se recolectaron datos sobre consultas de emergencia, ingresos hospitalarios, procedimientos invasivos, tratamiento y ocupación de áreas de internación. En ese periodo las consultas a emergencias y las hospitalizaciones disminuyeron en 75% y 48% respectivamente;los ingresos por angina de pecho y síndrome coronario agudo en 62% y los debidos a accidentes cerebrovascular e isquémico transitorio en 46%. Se encontró una disminución de las angioplastias coronarias (59%) e intervenciones percutáneas totales (65%), y un descenso tanto de las cirugías generales (73%) como de las cardíacas centrales (58%). Si bien el aislamiento social obligatorio es una estrategia clave de salud pública para aplanar la curva de propagación de la infección, la marcada disminución porcentual de consultas e intervenciones podría influir negativamente sobre la morbimortalidad cardiovascular, cerebrovascular y oncológica. Se requiere un esfuerzo conjunto para evitar una posible expansión del daño colateral del COVID-19. To contain the coronavirus pandemic (COVID-19), a strict nationwide lockdown has been enforced and the health systems have been reorganized to deal with this entity. During this period, changes in the care of non-infectious diseases have been observed. Our aim was to describe the impact of the COVID-19 pandemic in the care of non-communicable diseases. A structured retrospective survey was carried out in 31 healthcare centers affiliated with the Asociación de Clínicas, Sanatorios y Hospitales Privados de la República Argentina y Cámara de Entidades de Diagnóstico y Tratamiento. We compared data for April 2019 versus April 2020 regarding emergency room consultations, hospital admissions, invasive procedures and treatments, and bed occupancy. In April 2020, we observed a decrease in emergency room visits (75%) and hospitalizations (48%). A 62% decrease in admissions was noted for angina pectoris and acute coronary syndromes and a 46% decrease in admissions for stroke and transient ischemic attack. A meaningful decrease was found in coronary angioplasties (59%) and total percutaneous interventions (65%), and also a decrease in general surgeries (73%), and cardiac surgeries (58%). Although social distancing measures are a key public health strategy to flatten the infection curve, the observed decrease in medical visits and interventions may impact negatively on cardiovascular, cerebrovascular and cancer related morbidity and mortality. A collective effort is required to avoid the unintended consequences and collateral damage of the COVID-19 pandemic.

Paradoxical effect of SARS-CoV-2 infection in patients with immune thrombocytopenia.

Thrombocytopenia has been identified as a common complication of severe acute respiratory syndrome coronavirus-2 (SARS-CoV-2) infection in the general population. In an attempt to determine the impact of coronavirus disease 2019 (COVID-19) in patients with immune thrombocytopenia (ITP), a retrospective single-centre study was performed. Thrombocytosis was observed in patients with chronic ITP after SARS-CoV-2 infection, frequently needing treatment adjustment or even discontinuation of therapy. Relapses and newly diagnosed cases showed a fast response after initial treatment compared to ITP. Reduced immune activity due to lymphopenia during COVID-19 could explain this paradoxical effect, although further studies are needed.

Registry of patients with congenital bleeding disorders and COVID-19 in Madrid.

INTRODUCTION: We present the first registry of patients with congenital bleeding disorders and COVID-19. The study has been carried out in the Community of Madrid, which has the highest number of cases in Spain. The objective is to understand the incidence of COVID-19, the course of the disease if it occurs and the psychosocial and occupational impact on this population. METHODS: We included 345 patients (246 of haemophilia, 69 of von Willebrand Disease, two rare bleeding disorders and 28 carriers of haemophilia). A telephone survey was used to collect the data. RESULTS: Forty-two patients presented symptoms suggestive of infection by COVID-19, and in six cases, the disease was confirmed by RT-PCR. The cumulative incidence of our series was 1.73%. It is worth noting the complexity of the management of COVID-19 in two patients on prophylaxis with non-factor replacement therapy. Adherence to the prescribed treatment was maintained by 95.5% of patients. Although 94% were independent for daily living activities, 42.4% had a recognized disability and 58% required assistance, provided by the Madrid Haemophilia Association (Ashemadrid) in 75% of cases. Only 4.4% of consultations were held in person. CONCLUSIONS: Patients with congenital bleeding disorders infected with SARS-CoV-2 presented a mild course of the disease that did not require admission. Their identification and treatment by a specialist team from a Haemophilia Treatment Center are essential to make a correct assessment of the risk of haemorrhage/thrombosis. COVID-19 had a major impact on the psychosocial aspects of these patients which must be remedied with recovery plans.

Pre- and post-COVID-19 evaluation of antimicrobial susceptibility for healthcare-associated infections in the intensive care unit of a tertiary hospital.

INTRODUCTION: Antimicrobial resistance has worsened since the onset of COVID-19. METHODS: This study involved patients admitted to the adult intensive care unit (ICU) of a tertiary hospital. Pre- and post-COVID-19 data were analyzed. The healthcare-related infections (HCRIs) reported between January 2018 and January 2020 and during the pandemic between February and July 2020 were compared. RESULTS: Antimicrobial resistance increased during the pandemic, especially for Klebsiella pneumoniae isolates, with a rate increase from 5% to 50% for Polymyxin B. CONCLUSIONS: The susceptibilities of the main pathogens associated with HCRIs in the ICU changed and should be considered in managing severe COVID-19.

[Collateral damage of COVID-19 pandemic in private healthcare centres of Argentina]

To contain the coronavirus pandemic (COVID-19), a strict nationwide lockdown has been enforced and the health systems have been reorganized to deal with this entity. During this period, changes in the care of non-infectious diseases have been observed. Our aim was to describe the impact of the COVID-19 pandemic in the care of non-communicable diseases. A structured retrospective survey was carried out in 31 healthcare centers affiliated with the Asociacion de Clinicas, Sanatorios y Hospitales Privados de la Republica Argentina y Camara de Entidades de Diagnostico y Tratamiento. We compared data for April 2019 versus April 2020 regarding emergency room consultations, hospital admissions, invasive procedures and treatments, and bed occupancy. In April 2020, we observed a decrease in emergency room visits (75%) and hospitalizations (48%). A 62% decrease in admissions was noted for angina pectoris and acute coronary syndromes and a 46% decrease in admissions for stroke and transient ischemic attack. A meaningful decrease was found in coronary angioplasties (59%) and total percutaneous interventions (65%), and also a decrease in general surgeries (73%), and cardiac surgeries (58%). Although social distancing measures are a key public health strategy to flatten the infection curve, the observed decrease in medical visits and interventions may impact negatively on cardiovascular, cerebrovascular and cancer related morbidity and mortality. A collective effort is required to avoid the unintended consequences and collateral damage of the COVID-19 pandemic.

ACADEMIAS DE GINÁSTICA E EXERCÍCIOS FÍSICOS NO COMBATE À COVID-19: REFLEXÕES A PARTIR DA DETERMINAÇÃO SOCIAL DO PROCESSO SAÚDE-DOENÇA

O objetivo deste artigo é explicitar as contradições da defesa dos serviços oferecidos pelas academias de ginástica como essenciais à saúde em momentos de intensificação de casos da Covid-19. Analisou-se o modo como a concepção hegemônica que relaciona exercício físico e saúde é utilizada para justificar a reabertura destes estabelecimentos em momento de ascensão de casos e óbitos. Buscamos evidenciar como esse discurso assume um caráter ideológico. Apesar de ser uma necessidade, o exercício físico, produzido como mercadoria, apresenta seu valor de uso subsumido ao valor de troca, ou seja, é produzido prioritariamente para responder à necessidade de acumulação de capital. Reiteramos nossa concordância com a importância do exercício físico à saúde, mas problematizamos que deve ser considerado como uma necessidade historicamente produzida, portanto, articulada à particularidade de determinado momento histórico.Alternate abstract: The purpose of this article is to explain the contradictions when services provided by gyms are advocated as essential to health in times of the COVID-19 pandemic. We analyzed how the hegemonic conception that links exercise and health was used to justify the reopening of these establishments when cases and deaths are on the rise. We seek to show how this discourse takes on an ideological character. While exercising is necessary, as a commodity its value is subsumed under its exchange value, that is, it is produced primarily to respond to capital accumulation needs. We reiterate our agreement with the importance of exercising to health, but we question the universal character ascribed to it without considering it as a historically produced need and therefore linked to the specifics of a given historical time.Alternate abstract: El propósito de este artículo es explicitar las contradicciones existentes en la postura de defender los servicios que ofrecen los gimnasios como esenciales para la salud en momentos de intensificación de los casos de COVID-19. Se analizó la forma en que la concepción hegemónica que relaciona ejercicio físico y salud es utilizada para justificar la reapertura de estos establecimientos en momentos de aumento de casos y fallecimientos. Buscamos mostrar que este discurso adquiere un carácter ideológico. A pesar de ser una necesidad, el ejercicio físico, producido en forma de mercancía, presenta su valor de uso subsumido en el valor de cambio, es decir, se produce prioritariamente para responder a la necesidad de acumulación de capital. Reiteramos que estamos de acuerdo con la importancia del ejercicio físico para la salud, pero problematizamos que debe ser considerado como una necesidad históricamente producida y, por tanto, vinculada a la particularidad de un determinado momento histórico.